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Source: Experimental and Therapeutic Medicine

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Total 1347 results found since Jan 2013.

Accurate and continuous ultrasonography evaluation of small diameter vascular prostheses in vivo.
Authors: Shi J, Zhang J, Yin M, Wang Q, Du J Abstract There is a large clinical requirement for novel vascular grafts; however, the development of novel vascular grafts has not been extremely successful to date. The most successful method for the continuous evaluation of vascular grafts in vivo remains unclear. Therefore, an optimal successive, non-invasive imaging modality is necessary for the study of vascular transplantation. In the present study, a common rabbit model of carotid artery defect was utilized. The patency and hemodynamic characteristics of implanted grafts was examined following surgery by color Do...
Source: Experimental and Therapeutic Medicine - March 25, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

MicroRNA-146b induces the PI3K/Akt/NF- κB signaling pathway to reduce vascular inflammation and apoptosis in myocardial infarction by targeting PTEN.
In conclusion, microRNA-146b mediated vascular inflammation and apoptosis in patients with myocardial infarction, which may be associated with activation of the PI3K/Akt/NF-κB signaling pathway by PTEN. PMID: 30679990 [PubMed]
Source: Experimental and Therapeutic Medicine - January 28, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Salidroside prevents tumor necrosis factor- α-induced vascular inflammation by blocking mitogen-activated protein kinase and NF-κB signaling activation.
Salidroside prevents tumor necrosis factor-α-induced vascular inflammation by blocking mitogen-activated protein kinase and NF-κB signaling activation. Exp Ther Med. 2019 Nov;18(5):4137-4143 Authors: Li R, Dong Z, Zhuang X, Liu R, Yan F, Chen Y, Gao X, Shi H Abstract Vascular inflammation is a key factor in the pathogenesis of atherosclerosis. Salidroside is an important active ingredient extracted from the root of the Rhodiola rosea plant, which has been reported to have antioxidative, anti-cancer, neuroprotective and cardioprotective effects. However, the effects of salidroside on vascular inflamma...
Source: Experimental and Therapeutic Medicine - October 29, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Roles of klotho and stem cells in mediating vascular calcification (Review).
Authors: Yu L, Li M Abstract Vascular calcification, characterized by the active deposition of calcium phosphate in the vascular walls, is commonly observed in aging, diabetes mellitus and chronic kidney disease. This process is mediated by different cell types, including vascular stem/progenitor cells. The anti-aging protein klotho may act as an inhibitor of vascular calcification through direct effects on vascular stem/progenitor cells with osteogenic differentiation potential. A better understanding of the possible effects of klotho on vascular stem/progenitor cells may provide novel insight into the cellular an...
Source: Experimental and Therapeutic Medicine - October 4, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Rationality and necessity of vascular stapler application during liver resection (Review)
Exp Ther Med. 2021 May;21(5):498. doi: 10.3892/etm.2021.9929. Epub 2021 Mar 17.ABSTRACTLiver resection (LR) is the primary treatment method for patients with hepatocellular carcinoma (HCC). Improving surgical safety and reducing surgical morbidity and mortality is important for patients receiving LR. Various devices have been developed to facilitate vascular transection to reduce intraoperative blood loss, which is considered to be a predictor of poor surgical outcomes in patients undergoing LR. Vascular staplers have been widely applied for the division of major vascular and biliary structures in the process of LR; howeve...
Source: Experimental and Therapeutic Medicine - April 1, 2021 Category: General Medicine Authors: Er-Lei Zhang Zhi-Yong Huang Xiao-Ping Chen Source Type: research

Osteoprotegerin/receptor activator of nuclear factor- κB ligand are involved in periodontitis-promoted vascular calcification
In conclusion, OPG/RANK/RANKL may play an essential role in the promotion of vascular calcification by periodontitis. However, the expression levels of OPG and RANKL were not simply superimposed when periodontitis and vascular calcification co-existed.PMID:35813311 | PMC:PMC9260016 | DOI:10.3892/etm.2022.11439
Source: Experimental and Therapeutic Medicine - July 11, 2022 Category: General Medicine Authors: Mengyu Jiao Pengmei Zhang Xinbo Yu Pei Sun Meiwei Liu Yanya Qiao Keqing Pan Source Type: research

Effects of norepinephrine ‑induced activation of rat vascular adventitial fibroblasts on proliferation and migration of BMSCs involved in vascular remodeling
Exp Ther Med. 2023 May 3;25(6):290. doi: 10.3892/etm.2023.11989. eCollection 2023 Jun.ABSTRACTVascular remodeling caused by vascular injury such as hypertension and atherosclerosis is a complex process involving a variety of cells and factors, and the mechanism is unclear. A vascular injury model was simulated by adding norepinephrine (NE) to culture medium of vascular adventitial fibroblasts (AFs). NE induced activation and proliferation of AFs. To investigate the association between the AFs activation and bone marrow mesenchymal stem cells (BMSCs) differentiation in vascular remodeling. BMSCs were cultured with supernata...
Source: Experimental and Therapeutic Medicine - May 19, 2023 Category: General Medicine Authors: Jun Gao Li Li Dongli Zhou Xuhong Sun Lilu Cui Donglin Yang Xiaohui Wang Pengchao Du Wendan Yuan Source Type: research